Last data update: May 13, 2024. (Total: 46773 publications since 2009)
Records 1-2 (of 2 Records) |
Query Trace: Katz BZ[original query] |
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Clinical characteristics and genotypes of rotavirus in adults.
Anderson EJ , Shippee DB , Tate JE , Larkin B , Bregger MD , Katz BZ , Noskin GA , Sederdahl BK , Shane AL , Parashar UD , Yogev R . J Infect 2014 70 (6) 683-7 Immunity from a prior rotavirus infection is incomplete with infections occurring throughout life.1, 2, 3 Data suggest that rotavirus is responsible for 3–18% of adult diarrhea, particularly during the winter–spring.2, 3 We used data from our multi-year retrospective study2, 3, 4 of adults with community-acquired diarrhea from whom rotavirus was identified to describe the clinical characteristics, rotavirus genotypes, and predictors of adverse clinical outcomes. | The methods for this Institutional Review Board approved study have been published.2, 3, 4 Briefly, stool specimens from adults (≥18 years) submitted to Northwestern Memorial Hospital (Chicago, Illinois) for bacterial stool culture (BSC) were collected February–May from 2006 to 2011. Hospital-acquired diarrhea and duplicate specimens were excluded.2, 3, 4 Residual BSCs were analyzed for rotavirus by Rotaclone® and genotyped.2, 3, 4 Demographic information, medical co-morbidities, and outcomes were abstracted. Immunocompromised individuals were defined as previously outlined.2, 3 |
Detection of human parechovirus (HPeV)-3 in spinal fluid specimens from pediatric patients in the Chicago area
Walters B , Penaranda S , Nix WA , Oberste MS , Todd KM , Katz BZ , Zheng X . J Clin Virol 2011 52 (3) 187-91 BACKGROUND: The human parechoviruses (HPeV) have recently been recognized as important viral pathogens causing various illnesses including sepsis and meningitis in children. However, data from the United States is limited. OBJECTIVES: To better understand the epidemiology of HPeV in the United States and its role in pediatric disease through detection and typing of the virus in cerebrospinal fluid specimens. STUDY DESIGN: Four hundred and twenty-one spinal fluid samples collected from 373 patients ranging in age from 1 day to 18 years were tested using a real-time reverse transcription-PCR assay. The specimens were originally collected for routine viral and bacterial testing to assist in the diagnosis of meningitis or sepsis. Amplification products of the VP1 region in the virus genome were sequenced to identify the parechovirus type. RESULTS: Ten positive specimens were identified from 10 different patients. All ten samples were typed as HPeV3 and were negative for bacteria by culture, and for enterovirus and herpes simplex virus by PCR. All of the HPeV3-infected patients were young infants ranging in age from 6 to 59 days. Infants in whom HPeV3 was detected had significantly decreased peripheral white blood cell counts. Positive specimens were all from the summer and early fall. CONCLUSIONS: HPeV3 infection of the central nervous system is found in very young infants in certain years during the summer and early fall, and is associated with leukopenia. Real-time RT-PCR is an effective tool for rapid detection of these infections, and could help prevent unnecessary hospitalization and antibiotic use in HPeV infected infants. More widespread use of this tool in diagnosing HPeV infection would aid in further clarifying the prevalence of this disease in the United States. |
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